Welcome to the Vivek Prabhakaran Lab

Human Brain Mapping in Normals and Patient Populations

Research Strengths: Behavior, Cognition and Emotion; Neurobiology of disease; Development, Plasticity and Repair; Neuronal Circuits

Research Interests: Our laboratory is interested in utilizing neuroimaging tools to explore various questions at the 1) basic science 2) translational and 3) clinical levels. We're interested in using multimodal imaging tools incorporating fMRI, DTI, Perfusion Imaging, Cortical Thinning and other advanced MR imaging tools as well as collaborating with other labs using TMS/EEG and other neuroimaging techniques in order to accomplish this.

1. Basic science level: Developing cognitive models of memory and reasoning. Mapping neural substrates involved in cognitive processes such as working memory and reasoning and validating these brain maps using patient populations such as stroke patients.

2. Translational: Our lab is involved in characterizing the changes in these brain maps in normal aging as well as in different patient populations. One of the patient populations that our research lab is focused on is the Stroke population. We are involved with various groups at the university in the development of a stroke registry and tracking brain changes from the acute to chronic stages of stroke. Three areas of research focus within stroke in our laboratory involve the perfusion model of stroke, plasticity changes - neurorehabilitation, and vascular dementia

3. Clinical: fMRI/DTI is an exciting tool that is being developed for clinical use. fMRI and DTI are used for presurgical brain mapping prior to the resection of brain tumors, vascular lesions and epilepsy surgery. Brain mapping identifies functional structures involved in language, memory, vision, and sensorimotor processes to avoid during treatment. Our lab is interested in further developing these tools for clinical use along with FMRI/EEG for seizure localization and FMRI/TMS for validation of brain mapping.